Journal of Multidisciplinary Applied Natural Science
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https://doi.org/10.47352/jmans.2774-3047.327
Fathnur Sani Kasmadi
Yuliawati Yuliawati
Havizur Rahman
Agung Giri Samudra
Muhaimin Muhaimin
Diabetes mellitus is a serious threat to human health worldwide. Alternative therapy sources derived natural ingredients promise therapeutic benefits, safety, and cost savings. Nanoemulsion technology has demonstrated that natural extracts have improved bioavailability and therapeutic effects. This study aimed to demonstrate the efficacy of a nanoemulsion of Epipremnum pinnatum leaf extract, which has antidiabetic and antihyperlipidemic effects in alloxan-induced rats. The ideal nanoemulsion was formulated by testing four permutations of chitosan (0.1% or 0.2%; 18 mL), sodium tripolyphosphate (0.1% or 0.2%; 9 mL), combined with Epipremnum pinnatum extract (0.250 g) and Tween 80 (0.5%; 3 mL). The antidiabetic and antihyperlipidemic tests were divided into five treatment groups: normal group, negative control group (2 mL NaCMC/200g BW), positive control group (10 mg/kgBW of glibenclamide), treatment I (250 mg/kgBW of extract), and treatment II (250 mg/kgBW of nanoemulsion extract). The treatment lasted for 14 days, and the data taken were blood sugar, malondialdehyde (MDA), total cholesterol, triglyceride, LDL, and HDL levels. According to the results of Epipremnum pinnatum leaf extract nanoemulsion, the best nanoemulsion utilized in antidiabetic and antihyperlipidemic tests was one with a particle size of 165.70 nm and a zeta potential of 22.0 mV. The nanoemulsion administered at a dose of 250 mg/kg BW was more effective than the extract, and the effects were identical to those of glibenclamide. The data indicate that E. pinnatum leaf extract nanoemulsion could be used as an antidiabetic and antihyperlipidemic alternative treatment.
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